TCAs and SSRIs.

Level discernment should be taken when prescribing MAOIs in substance-using populations. Dietary restrictions are necessary because MAOIs can interact with tyramine in the diet resulting in a hypertensive occasion. Moreover, MAOIs in coalition with input substances may precipitate a hypertensive situation.


While clinical trials have demonstrated the efficacy of TCAs and the SSRIs in the care of terror physical condition in nonsubstance-using patients, these agents have not been systematically examined in comorbid populations with anxiety state. Interestingly, the SSRIs have been shown by some investigators to have modest effects in decreasing drinkable economic consumption, particularly in subgroups of alcoholics. While much work needs to be done in further defining the mathematical group of alcohol-dependent individuals most likely to respond to SSRIs, these agents may be a logical pick for the participant role with comorbid terror physiological state and passion.