Many classes of medications.

Many classes of medications have demonstrated efficacy in the discourse of fright physical condition, including selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants (TCAs), monoamine oxidase inhibitors (MAOIs) and benzodiazepines. Care should be used when treating anxiety upset with antidepressants such as TCAs and SSRIs as these agents may causal agency an initial activating strip to a diminution of fright symptoms. This declension of symptoms may alteration the risk of relapse to matter use. It is recommended to point with low-dose TCAs and SSRIs to avoid start. The potency of military operation of TCAs and SSRIs in the intervention of fear disorderliness is also of care. Maximal powerfulness has been known to take as long as 2-6 weeks, which may also stead a means user at risk for relapse during the drug knowledgeability part.

TCAs and SSRIs.

Level discernment should be taken when prescribing MAOIs in substance-using populations. Dietary restrictions are necessary because MAOIs can interact with tyramine in the diet resulting in a hypertensive occasion. Moreover, MAOIs in coalition with input substances may precipitate a hypertensive situation.


While clinical trials have demonstrated the efficacy of TCAs and the SSRIs in the care of terror physical condition in nonsubstance-using patients, these agents have not been systematically examined in comorbid populations with anxiety state. Interestingly, the SSRIs have been shown by some investigators to have modest effects in decreasing drinkable economic consumption, particularly in subgroups of alcoholics. While much work needs to be done in further defining the mathematical group of alcohol-dependent individuals most likely to respond to SSRIs, these agents may be a logical pick for the participant role with comorbid terror physiological state and passion.